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位置: eLearning Site of APLCGG > e-Learning > Nov 9-10, 2012,Seminars of Geriatric Research > Hypogonadism in Aging Male

Slide 1 (27:08)

by aplcgg, 2012-12-12 12:38, 人氣(2733)

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標題

1. Hypogonadism in Aging Male

2. The population structure in Taiwan

3. The population structure in Taiwan

4. Slide 4

5. Slide 5

6. Slide 6

7. Late-onset hypogonadism

8. T levels fall with age

9. Testosterone levels fall with age

10. Decline in Testosterone Levels is More Associated with Comorbid Conditions than with Age

11. Co-Morbidities in 2,162 Men in the HIM Study According to their Testosterone Levels

12. Relationship between BMI and Total T

13. Visceral fat is metabolically active and dangerous

14. Relationship between obesity and hypogonadism

15. A vicious cycle

16. Symptoms of hypogonadism

17. Clinical manifestations of late-onset hypogonadism

18. Why is it important to detect and treat hypogonadism?

19. Low testosterone is associated with increased mortality

20. Low T is associated with the ‘deadly quintet’

21. Why is low T associated with increased mortality risk?

22. Now recognized that low T is associated with CV risk factors

23. Why is low T associated with increased mortality risk?

24. Now recognized that low T is associated with CV risk factors

25. Men treated with GnRH agonists

26. Men treated with GnRH agonists die prematurely

27. Can TRT convert the CV risks?

28. Increasing evidence that TRT lowers risk factors for heart disease in low T men

29. Body Mass Index in 183 Hypogonadal Men after a total of2,135 Injections of Nebido® (maximal treatment duration 11 years)

30. Waist Circumference in 130 Hypogonadal Men after at least 8 Injections (total of 923 Injections) of Nebido®

31. LDL-Cholesterol in 183 Hypogonadal Men after a total of2,135 Injections of Nebido® (maximal Treatment Duration 11 yrs)

32. HDL-Cholesterol in 183 Hypogonadal Men after a total of2,135 Injections of Nebido® (maximal Treatment Duration 11 yrs)

33. Resting Systolic and Diastolic Blood Pressure (mm Hg) in 183 Hypogonadal Men after a total of 2,135 Injections of Nebido® (maximal Treatment Duration 11 years)

34. Testosterone Therapy with Nebido® for 1 yearImproves Body Composition in Elderly Men

35. Positive impacts of TRT

36. Testosterone Therapy with Nebido® for 1 year Improves BMD in Elderly Men

37. Effect of T gel for 24 weeks on dysthymia in hypogonadal men using Ham-D – remission rate

38. Testosterone Therapy with Nebido® for 1 year Improves BMD in Elderly Men

39. Effect of T gel for 24 weeks on dysthymia in hypogonadal men using Ham-D – remission rate

40. Aspects of LOH remain controversial

41. Paucity of Rx long term safety datafurther research is needed e.g. WHI type study to clarify benefits and risksin 2004 US Institute of Medicine recommend small, placebo-controlled trials to prove benefit and then, if the results are positive, larger studies to prove safety*In the meantime a conservative approach is recommended treat only when men have overt androgen deficiency with proven low Tscreen carefully before Rxmonitor closely

42. Practice point

43. Take-home messages

44. Thank you

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