John Pemberton’s 90th birthday - eLearning Site of APLCGG

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位置: eLearning Site of APLCGG > e-Learning > Geriatrics Fellowship Teaching Schedule > TGVH fellows Frailty and Sarcopenia Sept 10 2013

John Pemberton’s 90th birthday (1:14:39)

by aplcgg, 2013-09-23 14:25, 人氣(987)

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標題

1. Frailty and Sarcopenia

2. Frailty and Sarcopenia

3. Summary

4. FRAILTY - Origins of the term

5. FRAILTY - Origins of the term

6. FRAILTY - Origins of the term

7. Usual and successful - heterogeneity

8. Sources of variability operate throughout the lifespan

9. Origins of the term

10. Lets look at the transitions involved (based on the WHO ICF model)

11. Lets look at the transitions involved (based on the WHO ICF model)

12. Origins of the term

13. Cross sectional snapshot of the older population

14. Concepts of frailty

15. Concepts of frailty

16. Risk factor prediction approach

17. Fried’s criterion based definition Fried LP et al J Gerontol A Biol Sci Med Sci 2001; 56: M146-56

18. Survival curves over 4 years (Fried’s study)

19. Rockwood Frailty Index – Deficit Accumulation Model

20. Rockwood Frailty Index – Deficit Accumulation Model

21. Baseline and Follow up Rockwood Frailty Index

22. Survival curves over 4 years (Fried’s study)

23. Baseline and Follow up Rockwood Frailty Index

24. Patho-physiological causal approach to Frailty

25. What might cause Frailty –the pathophysiological causal pathway 1

26. What might cause Frailty –the pathophysiological causal pathway 2

27. Example of muscle as key target for these processes - SARCOPENIA

28. Sarcopenia – Irving Rosenberg 1989

29. Which aspects of muscle matter?

30. Muscle strength & mortality

31. Muscle function and clinical outcomes

32. Cachexia, sarcopenia, starvation, frailty -overlapping conditions

33. The nature of sarcopenia

34. Diagnosis of sarcopenia

35. Development of sarcopenia is not linear

36. Component contributions to end result

37. How might muscle be lost ?

38. Motor neurone effects

39. Motor neurone effects

40. What biological mechanisms might lead to loss of muscle mass and function?

41. Physical activity effects 1

42. Physical activity effects 2

43. Reduced net anabolic hormone profile

44. Ageing and GH decline (somatopause)

45. Growth hormone replacement RCTs

46. Ageing and MGF

47. “Counter-regulation” by myostatin

48. Testosterone

49. Oestrogens

50. Oestrogens

51. Vitamin D

52. Some clues from the hormonal changes in strength trainingN.B. The opposite of changes associated with ageing

53. Slide 44

54. Some clues from the hormonal changes in strength trainingN.B. The opposite of changes associated with ageing

55. Slide 44

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